NUI Galway Bacterial Infection Project Awarded SFI Funding

Dr Joseph Byrne, School of Chemistry, NUI Galway. Photo: Science Foundation Ireland
Jan 24 2019 Posted: 10:07 GMT

NUI Galway has been awarded almost €420,000 in funding for developing new technology for faster clinical detection and diagnosis of bacterial infections such as Pseudomonas aeruginosa, a key cause of mortality in Cystic Fibrosis patients.

Dr Joseph Byrne from NUI Galway received his award as part of a government investment of €10.8 million in Irish research funding through Science Foundation Ireland’s (SFI) Starting Investigator Research Grant (SIRG), announced by Minister of State for Trade, Employment, Business, EU Digital Single Market and Data Protection, Pat Breen TD. With awards ranging from €376,000 to €425,000 over four years, the projects funded will support 20 researchers and a further 20 PhD students in the research areas of health, energy, environment, materials and technology.

Many disease-causing bacteria produce proteins, which are known to interact with sugar molecules. These interactions will allow the design of useful sensors. Dr Byrne’s research will develop novel devices that will indicate the presence of specific bacteria through colour changes, caused by the interactions of their proteins with laboratory-produced sugar-based chemical compounds on the surface of newly-designed materials. This will provide a convenient visual strategy to identify disease-causing bacteria. 3D-printing will be used to create these compact diagnostic devices, which will benefit patient outcomes and quality of life. This new technology could also be deployed in other scenarios such as detecting bacterial contamination of water supplies.

Speaking about his funding award, Dr Joseph Byrne from NUI Galway, said: “Rapid diagnosis of bacteria is vital to inform appropriate medical treatment strategies and combat increasing antibiotic resistance globally. By providing a new methodology for rapid diagnosis of bacterial infection, my work will facilitate quicker decision-making on targeted medical treatment strategies for patients. In Ireland this would be particularly valuable for rapid diagnosis of Pseudomonas aeruginosa infections, a significant risk factor for cystic fibrosis patients (as well as others with compromised immune systems). More generally, helping clinicians avoid the use of broad-spectrum antibiotics would help combat the global challenge of increased antibiotic resistance.”   

Speaking about the awards, Minister Breen said: “I am delighted to announce these SFI Starting Investigator Awards which allow researchers to advance their work and further develop their careers as the next research leaders in Ireland and internationally. These innovative projects demonstrate the impressive cutting-edge research taking place across Ireland, which has significant potential to positively advance Ireland’s economy and society, and further solidify its reputation as a world-leader in scientific advancements.”

Welcoming the announcement, Professor Mark Ferguson, Director General of Science Foundation Ireland and Chief Scientific Adviser to the Government of Ireland, said: “Science Foundation Ireland supports researchers at every stage of their careers. The SIRG awards help early-career researchers develop the essential skills and experience necessary to lead Ireland’s future research in areas such as health, energy, materials and technology. Having passed through a rigorous competitive international merit review process, these projects continue to advance Ireland’s international research.

A native of Newbridge, Co. Kildare, Dr Joseph Byrne joins the School of Chemistry and CÚRAM, the Science Foundation Ireland Centre for Research in Medical Devices at NUI Galway, following a Marie Curie Research Fellowship at Universität Bern, Switzerland. His main research focus is developing new technology for faster clinical diagnosis of bacterial infections by exploiting interactions between biomolecules and the innovative sensor materials, which will be designed during the course of this SIRG project. The research will be multidisciplinary, building on fundamental chemistry and biochemical interactions to develop diagnostic devices using 3D-printing technology.

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